A.M.M. Safiullah studied in East Pakistan Cadet College (later renamed to Faujderhat Cadet College). He earned his bachelor's and master's in civil engineering from BUET in 1969 and 1977 respectively. He obtained his Ph.D. degree from the University of Strathclyde in 1981 with a Commonwealth Scholarship.
A.M.M. Safiullah joined BUET as a lecturer in Civil Engineering in 1973 and eventually became a professor in 1984. He held the position of the 10th Vice Chancellor of BUET from August 2006 until August 2010. He was among the panel of experts appointed by the Government of Bangladesh for construction of Bangabandhu Bridge. Now he is working in the panel of experts for construction of Padma Bridge, the largest structure under construction in Bangladesh.